调查研究
胆舒软胶囊治疗胆囊结石伴疼痛的临床效果评价
候明星
【摘要】 【摘要】目的 评价胆舒软胶囊对胆囊结石伴发疼痛的治疗效果。方法 A试验选取2018年12月至2019年11月为期一年的门诊慢性结石性胆囊炎伴右上腹隐痛患者共74例，35例观察组口服胆舒软胶囊，39例对照组口服消炎利胆片；B试验选取同期急诊入院治疗的胆囊结石伴急性胆绞痛患者共101例，53例观察组口服胆舒软胶囊，48例对照组口服消炎利胆片。以服药后疼痛变化为观察指标，计算治疗有效率，利用统计学方法分别对两个试验数据进行分析。
【关键字】 胆囊结石,疼痛,胆舒软胶囊
中图分类号：文献标识码：文章编号：
[Abstract] Objective To evaluate the therapeutic effect of Danshu Soft Capsule on gallstone accompanied by pain. Methods The trial A selected 74 outpatients with chronic calculous cholecystitis accompanied by right upper abdominal cryptodynia from December 2018 to November 2019. 35 cases in the observation group took Danshu Soft Capsule orally and 39 cases in the control group took XiaoyanLidan Tablets orally. In the B trial, 101 cases of gallstones accompanied by acute biliary colic were selected for emergency admission treatment in the same period as trial A,53 cases in the observation group,takingDanshu Soft Capsule, 48 cases of control group took XiaoyanLidan Tablet orally. Taking the pain changes after taking medicine as the observation index, the effective rate of treatment was calculated, and the data of the two experiments were analyzed by statistical method. Results In experiment A, the effective rate of the observation group was 80.0%, while that of the control group was 76.9%. There was no statistical difference between the two groups. In experiment B, the effective rate of the observation group was 78.0%, and that of the control group was 59.1%, with statistical significance (P＜0.05). Conclusion Anshu Soft Capsule and XiaoyanLidan Tablet have good effect in the treatment of chronic calculous cholecystitis with epigastric cryptodynia, and both of them have the same effect;Danshu Soft Capsule may be superior to XiaoyanLidan Tablet in the effective rate and the speed of relieving pain for the treatment of Acute biliary colic.
胆囊结石是一种名副其实的常见病、多发病，我国胆囊结石发病率为7%~10%[1]，而西方国家成人发病率高达15%[2]。胆囊结石的典型症状为胆绞痛，表现为急性右上腹痛伴节律性加重，多发生于餐后或夜间；也有患者表现为上腹隐痛不适等非典型症状，但多数胆囊结石患者可无任何症状[3-4]。如果有明显症状或并发症，或出现并发症的风险较高，这类情况以手术治疗为主[5]，然而在实际治疗过程中，部分患者因症状不严重或无手术意愿而选择药物对症治疗，胆囊结石导致的疼痛通常使用镇痛药物或解痉药物对症处理[6]。有临床证据表明，部分中成药物如消炎利胆片对胆囊结石、胆囊炎导致的疼痛具有一定治疗作用[7-8]，胆舒软胶囊亦因具有类似的效果而作为治疗胆囊结石、胆囊炎的常用药物，为验证胆舒软胶囊的疗效，故以消炎利胆片为对照，设计了如下试验。
1 资料与方法
1.1 一般资料：A试验选取2018年12月至2019年11月为期一年的门诊慢性结石性胆囊炎伴右上腹隐痛患者共74例，一般资料见表1。
