调查研究
支原体肺炎患儿应用小儿豉翘清热颗粒联合阿奇霉素治疗的观察
赵男
【摘要】 【摘要】目的 探讨支原体肺炎患儿应用小儿豉翘清热颗粒联合阿奇霉素治疗的效果。方法 选择我院100例2017年6月至2018年1月支原体肺炎患儿。随机分组，阿奇霉素组采取阿奇霉素治疗，中西医药物联合治疗组则采取阿奇霉素联合小儿豉翘清热颗粒治疗。比较两组支原体肺炎疗效；炎症因子恢复正常的时间、咳嗽症状消失时间、喘息消失时间、发热消失时间；治疗前后患儿第一秒用力呼气容积、最大呼气流量、肺活量、肿瘤坏死因子-α、C反应蛋白；不良反应。
【关键字】 支原体肺炎,小儿豉翘清热颗粒,阿奇霉素,治疗效果
中图分类号：文献标识码：文章编号：
[Abstract]Objective To investigate the effect of Xiaoerqin Qingre Granule combined with Xiaoerchiqiaoqingrekeli in children with mycoplasmal pneumonia. Methods 100 children with mycoplasma pneumonia from June 2017 to January 2018 were enrolled in our hospital. Randomly, the Xiaoerchiqiaoqingrekeli group was treated with Xiaoerchiqiaoqingrekeli, and the combination of Chinese and Western medicine was treated with Xiaoerchiqiaoqingrekeli combined with Xiaoerchiqiaoqingrekeli Granule. Comparison of the efficacy of mycoplasmal pneumonia in two groups; time to return to normal inflammatory factors, time to disappear cough symptoms, time to disappear from wheezing, time to disappear from fever; forced expiratory volume in the first second before and after treatment, maximum expiratory flow, vital capacity, tumor necrosis factor- α, C-reactive protein; adverse reactions. Results The efficacy of mycoplasmal pneumonia in the combined treatment group of Chinese and Western medicine, the time when inflammatory factors returned to normal, the time of disappearance of cough symptoms, the time of disappearance of wheezing, the time of disappearance of fever, the forced expiratory volume in the first second, the maximum expiratory flow, vital capacity, tumor necrosis factor-α, C-reactive protein was better than the Xiaoerchiqiaoqingrekeli group, P<0.05. The adverse reactions of the combination of Chinese and Western medicine in the treatment group were less than those in the Xiaoerchiqiaoqingrekeli group. Conclusion Xiaoerchiqiaoqingrekeli Granule combined with Xiaoerchiqiaoqingrekeli is effective in treating mycoplasmal pneumonia, which can effectively improve symptoms and lung function, control inflammation index, and no serious adverse reactions.
支原体肺炎在儿童中发病率很高，在临床实践中更为常见，对儿童的生活质量有很大影响。有针对性地使用抗生素是改善症状和促进康复的重要措施。但单一抗生素治疗效果有限[1]。本研究选择我院100例2017年6月至2018年1月支原体肺炎患儿。随机分组，阿奇霉素组采取阿奇霉素治疗，中西医药物联合治疗组则采取阿奇霉素联合小儿豉翘清热颗粒治疗。比较两组支原体肺炎疗效；炎症因子恢复正常的时间、咳嗽症状消失时间、喘息消失时间、发热消失时间；治疗前后患儿第一秒用力呼气容积、最大呼气流量、肺活量、肿瘤坏死因子-α、C反应蛋白；不良反应，分析了支原体肺炎患儿应用小儿豉翘清热颗粒联合阿奇霉素治疗的效果，报道如下。
1 资料与方法
1.1 一般资料：选择我院100例2017年6月至2018年1月支原体肺炎患儿。随机分组，其中，阿奇霉素组年龄2~11（6.15±2.12）岁。男女分别35例和15例。支原体肺炎病程2~12 d，平均（5.91±0.55）d。中西医药物联合治疗组年龄2-12（6.14±2.71）岁。男女分别34例和16例。支原体肺炎病程2~11 d，平均（5.67±0.67）d。阿奇霉素组、中西医药物联合治疗组资料有可比性。
1.2 方法：阿奇霉素组采取阿奇霉素治疗，阿奇霉素剂量是10 mg/（kg•d），将其混合250 mL生理盐水缓慢静滴，每天1次，用药第五天停止治疗，再过4 d按照10 mg/kg口服，每天2次，治疗2周。中西医药物联合治疗组则采取阿奇霉素联合小儿豉翘清热颗粒治疗。小儿豉翘清热颗粒剂量是1 g，每天3次，冲温水服用，治疗2周。
1.3 指标：比较两组支原体肺炎疗效；炎症因子恢复正常的时间、咳嗽症状消失时间、喘息消失时间、发热消失时间；治疗前后患儿第一秒用力呼气容积、最大呼气流量、肺活量、肿瘤坏死因子-α、C反应蛋白；不良反应。显效：第一秒用力呼气容积、最大呼气流量、肺活量、肿瘤坏死因子-α、C反应蛋白复常，咳嗽、发热和喘息等症状体征消失；有效：第一秒用力呼气容积、最大呼气流量、肺活量、肿瘤坏死因子-α、C反应蛋白、咳嗽、发热和喘息等症状体征改善一半以上；无效：第一秒用力呼气容积、最大呼气流量、肺活量、肿瘤坏死因子-α、C反应蛋白改善的程度低于50%。疗效=显效、有效百分率之和[2]。
1.4 统计学处理：SPSS16.0软件进行数据处理，计量数据进行t检验，计数数据进行χ2检验，P＜0.05说明有统计学意义。
