应用研究
原发性肝癌化疗栓塞风险的多因素分析
于杉
【摘要】 【摘要】目的 研究原发性肝癌化疗栓塞风险的多因素。方法 研究选择了我院收治的原发性肝癌患者80例为研究对象。结果 Child-Pugh分级回归系数为0.862，标准误为0.741，危险值为7.189，Wald为9.147，P＜0.05；
【关键字】 原发性肝癌,化疗栓塞术,风险因素
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[Abstract]Objective To study the multiple factors of chemotherapy and embolization risk of primary liver cancer. Methods Eighty patients with primary liver cancer admitted to our hospital were selected as the research subjects. Results Child-Pugh graded regression coefficient was 0.862, standard error was 0.741, risk value was 7.189, Wald was 9.147, P<0.05; portal vein tumor thrombus regression coefficient was 0.338, standard error was 0.128, risk value was 8.247, and Wald was 6.547. P<0.05; the regression coefficient of iodized oil deposition was 0.448, the standard error was 0.318, the risk value was 7.296, and the Wald was 7.317, P<0.05. Conclusion Patients with primary liver cancer are susceptible to many different factors during chemotherapy embolization. Impacts, which in turn lead to risk issues, require health care providers to provide comprehensive and scientific treatment options that reduce the adverse effects of risk factors on patients.
原发性肝癌是一种高发性和高病死率的疾病类型，对于人们的身体健康和生命安全产生了严重的威胁[1]。肝动脉化疗栓塞术是一种介入手术，治疗的过程中，可以充分降低患者机体的损伤[2]。但是此种方法使用，容易加剧患者的肝功能损伤[3]。本文主要对原发性肝癌患者化疗栓塞风险因素进行研究，具体研究报道如下。
1 资料与方法
1.1 一般资料：本文在研究选择了我院收治的原发性肝癌患者80例为研究对象，男性患者56例，女性患者24例。患者年龄区间在41~82岁，平均年龄为（61.28±2.15）岁。患者的病程从1~5年，平均病程为（3.14±0.11）年。一般资料差异无统计学意义（P＞0.05）。
1.2 方法：①使用肝动脉造影和TACE术对患者进行治疗[4]。②对患者的肝硬化程度和肿瘤大小进行检测，注入不同剂量的化学治疗药物，具体分为丝裂霉素、5-氟尿嘧啶、吡柔比星和顺铂等药物，搭配使用明胶海绵栓塞剂[5]。
1.3 观察指标：①使用Cox回归线性分析方程，对患者的 Child-Pugh分级、门静脉癌栓和碘油沉积情况情况进行计算；②对治疗后3年内，患者生存率进行统计。
1.4 统计学方法：应用统计学软件SPSS24.0。P＜0.05，表示组间差异有统计学意义。