临床研究

药物过度性头痛患者应用都梁软胶囊联合加巴喷丁治疗的临床分析

吴洋 康玲伶*

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【摘要】  【摘要】目的 探讨都梁软胶囊联合加巴喷丁在治疗药物过度性头痛患者中的应用效果。方法 2018年1月至2019年5月就诊于承德医学院附属医院的40例药物过度性头痛患者作为研究对象。按照入院编号单双数法分为治疗组20例,对照组20例,比较两组患者的治疗效果以及不良反应情况。

【关键字】  药物过度性头痛,都梁软胶囊,加巴喷丁,不良反应

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[Abstract]Objective To compare the effect of duliang soft capsule combined with gabapentin in the treatment of patients with meadication overuse headache. Methods 40 patients with meadication overuse headache who were admitted to the affiliated hospital of chengde medical college from January 2018 to May 2019 were studied.According to the admission number, 20 Subjects were divided into the treatment group and the control group, and the treatment effects and adverse reactions of the two groups were compared. Results After treatment, the VAS score of headache in the treatment group decreased by 53.4%, and that in the control group decreased by 22%. The treatment group was significantly higher than the control group, and the difference was statistically significant. Conclusion Duliang soft capsule combined with gabapentin is effective in the treatment of patients with excessive headache.

药物过度性头痛(medcation overuse headache,MOH)是继发性头痛的一种,指由于频繁过度应用急性止痛药物而导致头痛加重。流行病学资料显示,MOH在全球范围内的总患病率为0.5%~2.6%[1],在我国MOH的患病率为0.6%[2]。因MOH频繁发作,严重影响患者正常生活,给患者带来痛苦及经济负担。关于MOH预防性治疗时可以采用加巴喷丁药物,尽管得到了有效的治疗,但长期应用过程中会增加耐药性,进而影响治疗效果。临床上严重头痛患者可采用联合用药治疗头痛。报道如下。 1 资料与方法 1.1 一般资料:将2018年1月至2019年5月就诊于承德医学院附属医院的药物过度性头痛患者40例,按照入院编号单双数发分为两组:都梁软胶囊联合加巴喷丁组(治疗组)20例,其中男性5例,女性15例,年龄37~82岁,平均年龄(59.55±13.45)岁;单用加巴喷丁组(对照组)20例,其中男性7例,女性13例,年龄45~84岁,平均年龄(63.15±8.29)岁。治疗组治疗前头痛强划分为轻度疼痛、中度疼痛、重度疼痛,依次为4例、7例和9例,对照组依次为3例、7例和10例。比较两组性别比例、年龄和头痛程度均无统计学差异(P >0.05)。 1.2 病例入选标准:符合国际头痛分类诊断标准中药物过度性头痛的诊断标准,即①原发性头痛患者每月头痛发作的天数≥15;②规律服用过量的急性或症状性头痛治疗药物3个月以上;③不能用ICHD-3中的其他诊断更好地解释。患者志愿受试并签署知情同意书。

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