胶质瘤是人类中枢神经系统最常见的肿瘤，它的主要生物学特性为局部侵袭性生长而罕见颅外转移。脑胶质瘤细胞的侵袭性生长和复发是胶质瘤临床治疗失败的主要原因。研究发现，黏附分子家族中的整合素参与了肿瘤细胞的黏附和迁移等多个环节，通过介导细胞与细胞外基质蛋白、细胞之间的黏附和信号转导等作用，直接和间接地影响肿瘤细胞的侵袭性，包括胶质瘤细胞的侵袭性[1]。整合素家族的配体主要是细胞外基质成分。在正常脑组织中，血管基底膜和胶质界膜处的细胞外基质主要包括W型胶原蛋白、纤维粘连蛋白(FN)、层粘连蛋白(LN)和玻粘连蛋白等[2，3]。我们采用免疫组织化学方法检测了脑胶质瘤中整合素β1、纤维粘连蛋白表达，了解二者在脑胶质瘤组织中的表达情况，并分析它们与肿瘤分化程度及侵袭转移的关系。
论著
纤维粘连蛋白和整合素β1在人脑胶质瘤中的表达及其意义
赵杰 刘跃亭*
【摘要】 目的 研究纤维粘连蛋白、整合素β1在胶质瘤中的表达及其与恶性程度的相关性，探讨纤维粘连蛋白、整合素β1在人脑胶质瘤的诊断及恶性程度判断中的临床意义。方法 应用免疫组织化学的方法检测60例脑胶质瘤组织标本、15例正常脑组织标本中纤维粘连蛋白、整合素β1的表达。
【关键字】 胶质瘤,纤维粘连蛋白,整合素β1
中图分类号：R739.41文献标识码：B文章编号：1671-8194（2011）01-0025-03
The Expression and Significance of Fibronectin and Integrin β1 in Human Brain Glioma
ZHAO Jie, LIU Yue-ting
(Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China)
[Abstract] Purpose To explore the expression of fibronectin and integrinβ1 in human glioma cell of the patientswith neurogliocytoma and to see whether or not fibronectin and integrinβ1 expression associate with thedifferentiation and pathologic grading. It was expected that this study could reveal some essentialqualities of the glioma and provide potential application for judging the malignant grades andbiological treatment. Methods The expression of fibronectin and integrinβ1 was detected in 60 cases of human glioma and 15 specimens of normal brain tissues by immunohistochemistry staining. Result Normal brain tissue specimens of Fibronectin and integrin β1 did not express.The positive rates of fibronectin were 31.67% (19/60) in glioma.The positive rates of fibronectin increased along with the elevation of glioma malignancy(P<0.05). The positive rates of integrinβ1 were 40.00%(24/60) in glioma.The positive rates of integrinβ1 increased along with the elevation of glioma malignancy(P<0.05). Significant positive correlation was observed between the expression of fibronectin and integrinβ1(r=0.518, P<0.05). Conclusion The positive correlation existed between the expression of fibronectin and integrinβ1 and the pathological grading of the human glioma.Detecting fibronectin and integrinβ1 in the human glioma can be used in diagnosing, judging the malignancy degree and the prognosis.