论著
奥卡西平治疗癫痫的临床效果观察
曾凡明
【摘要】 目的 探讨奥卡西平治疗癫痫的临床效果。方法 选择2007年1月至2009年10月门诊或住院治疗的64例癫痫患者，随机分为治疗组和对照组各32例，治疗组用奥卡西平治疗，对照组用苯妥英钠治疗，比较两组疗效和不良反应。
【关键字】 奥卡西平,癫痫,苯妥英钠,疗效
中图分类号：R742.1文献标识码：B文章编号：1671-8194（2011）01-0016-02
Clinical Effect Observation of Oxcarbazepine to Treat Epilepsy
ZENG Fan-ming
Huaihua Second People’s Hospital, Huaihua 418200, China
[Abstract] Objective To explore the clinical effect of oxcarbazepine to treat epilepsy. Method Select 64 epilepsy patients that treated in our hospital, who are randomly divided into treat group and control group, 32 patients each group, the treat group are treated with oxcarbazepine and the control group are treated with phenytoin, compare their treat effect and adverse effect. Results the total effect of treat group is 87.5%, which of the control group is 68.8%, the difference has statistical significance（P<0.05）, the treat effect of treat group is better than control group; 4 patients of the treat group have adverse effect, the rate is 12.5%, 11 patients of the control group have adverse effect, the rate is 34.3%, the difference is statistical significant（P<0.05）. Conclusion It has good effect of using oxcarbazepine to treat epilepsy and can be widely used in clinic.
癫痫是神经系统的常见疾病，多见于儿童和青少年，主要表现为由于脑神经过度放电引起的以反复发作和短暂性发作为主要特征的慢性脑部疾病，治疗癫痫主要依靠抗癫痫药物，以求能恢复或者保持患者原有的身心状态和生活、学习、工作能力为主要目标，传统的抗癫痫药物如苯妥英钠、卡马西平等虽也有较好的疗效，能够控制70%~80%的患者发作，但也有明显的缺点，如不良反应严重、药物间可以相互作用等。奥卡西平(oxcarbazepine，oxc)是一种新型的抗癫痫药物，最早于2000年被美国FDA批准上市，目前国内对奥卡西平的研究尚不多见，我们应用奥卡西平治疗癫痫患者，取得一定效果，现将结果报道如下。
