线粒体DNA编码蛋白质亚基的研究

陈飞雄1 申林娜2 蒲军1 徐蔚1

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【摘要】  人类线粒体DNA(mtDNA)是全长为16569 bp的双链闭环分子，除负责编码2种rRNA和22种tRNA外，还参与了4种呼吸酶复合物(13种多肽)的形成。本文就人线粒体DNA编码的各蛋白亚基的结构、功能和研究进展进行综述。

【关键字】  线粒体基因组,线粒体,NADH-CoQ还原酶,泛醌-细胞色素C还原酶,细胞色素C氧化酶,ATP合成酶

中图分类号：Q5文献标识码：A文章编号：1671-8194（2011）01-0006-03

The Research Progress of Protein Subunits Coded by The Mitochondrial DNA

CHEN Fei-xiong¹, SHEN Lin-na², PU Jun¹, XU Wei¹

(1 Department of Neurosurgery, The 2nd of Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101,China; 2 Department of Neurology, The 2nd of Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101,China）

[Abstract]The total length of the human mitochondrial DNA(double loop molecular chain)was 16,569 bp, the genome content of human including 2 rRNA,22 tRNA, and 13 protein-coding genes. The 13 protein-coding genes were NADH dehydrogenase subunits 1-6 and 4L genes; cytochrome c oxidase subunits I-III genes; cytochrome b gene; ATPase subunits 6 and 8 genes; In the present review ,the composition, the structure and function, the most significant studies on the 13 protein-coding genes are reported.